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QE: MBS vs treasuries

QE1 purchased MBS, QE2 purchased treasuries, and QE3 is expected to be targeted towards MBS.  What are the motivations and/or advantages to picking one over the other?  
Bernanke seems to be very interested in the makeup of the Fed balance sheet, I’m just not sure I completely understand his logic.
Source:  http://blogs.wsj.com/economics/2009/01/13/bernanke-you-say-quantitative-easing-i-say-credit-easing/

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